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Antinociceptive and 'neurotoxic' actions of somatostatin in rat spinal cord after intrathecal administration. 1988
Peter Mollenholt, and
Claes Post, and
Narinder Rawal, and
Jacob Freedman, and
Tomas Hökfelt, and
Ivar Paulsson
Department of Anaesthesia and Intensive Care, Örebro Medical Centre Hospital, S-701 85 ÖrebroSweden Astro Research and Development Laboratories and Astra Toxicological Laboratories, S-I5I 85 SödertäljeSweden Department of Histology, Karolinska Institute, S-104 01 StockholmSweden.
In the present investigation, the antinociceptive effect of somatostatin (SST) was assessed after intrathecal injection in rats. It was found that the peptide caused antinociception, hind limb paralysis and neuronal damage of the spinal cord in a dose-dependent manner. The threshold dose for antinociception was lower (approximately 10 micrograms) than that (approximately 30 micrograms) giving rise to chronic motor impairment associated with necrotic changes and loss of an immunohistochemical marker for motoneurons in the spinal cord. It is concluded that the 'neurotoxic' potential of SST should be considered in further clinical trials.
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