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1. The effects of tulobuterol on the atrial rate was compared with those of isoproterenol, pindolol and propranolol in spontaneously beating isolated right atria of the rat. 2. Isoproterenol markedly increased atrial rate. To the contrary, propranolol, pindolol and tulobuterol decreased atrial frequency. The chronotropic effect of tulobuterol was similar to that of pindolol but lower than that of propranolol. 3. Interactions between tulobuterol and isoproterenol showed that tulobuterol potentiated the chronotropic effect of low concentrations of isoproterenol but reduced the positive chronotropic response to higher concentrations of isoproterenol. 4. These results suggest that tulobuterol is a partial agonist on atrial beta-receptor but also seems to have another action (possibly a membrane stabilizing activity) which reduced the originally induced effect on beta-receptors as a non-competitive antagonist.
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
January 1985,
International journal of clinical pharmacology, therapy, and toxicology,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
January 1997,
British journal of clinical pharmacology,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
April 1983,
The New England journal of medicine,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
June 1984,
Canadian journal of physiology and pharmacology,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
January 1982,
British journal of clinical pharmacology,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
March 1984,
Canadian journal of physiology and pharmacology,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
June 1981,
European heart journal,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
March 1984,
Clinical pharmacology and therapeutics,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
September 1980,
The Journal of pharmacy and pharmacology,
L Gonzalez-Sicilia, and
E Perez-Ojeda, and
M L Laorden, and
A J Brugger, and
J Hernandez
May 1985,
American heart journal,
