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Analysis of sequence data to identify potential risk variants for oral clefts in multiplex families. 2017

Emily R Holzinger, and Qing Li, and Margaret M Parker, and Jacqueline B Hetmanski, and Mary L Marazita, and Elisabeth Mangold, and Kerstin U Ludwig, and Margaret A Taub, and Ferdouse Begum, and Jeffrey C Murray, and Hasan Albacha-Hejazi, and Khalid Alqosayer, and Giath Al-Souki, and Abdullatiff Albasha Hejazi, and Alan F Scott, and Terri H Beaty, and Joan E Bailey-Wilson
Computational and Statistical Genomics BranchNational Human Genome Research InstituteNational Institutes of HealthBaltimoreMaryland.

BACKGROUND Nonsyndromic oral clefts are craniofacial malformations, which include cleft lip with or without cleft palate. The etiology for oral clefts is complex with both genetic and environmental factors contributing to risk. Previous genome-wide association (GWAS) studies have identified multiple loci with small effects; however, many causal variants remain elusive. METHODS In this study, we address this by specifically looking for rare, potentially damaging variants in family-based data. We analyzed both whole exome sequence (WES) data and whole genome sequence (WGS) data in multiplex cleft families to identify variants shared by affected individuals. RESULTS Here we present the results from these analyses. Our most interesting finding was from a single Syrian family, which showed enrichment of nonsynonymous and potentially damaging rare variants in two genes: CASP9 and FAT4. CONCLUSIONS Neither of these candidate genes has previously been associated with oral clefts and, if confirmed as contributing to disease risk, may indicate novel biological pathways in the genetic etiology for oral clefts.

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