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Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians. 2017
Philippine Eloy, and
Adrien Tessier, and
Patty Fan-Havard, and
Monidarin Chou, and
Céline Verstuyft, and
Anne-Marie Taburet, and
David W Haas, and
Julie Bertrand, and
Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between CYP2B6 polymorphisms and metabolite ratios for both 3-hydroxynevirapine and 8-hydroxynevirapine, suggesting involvement of CYP2B6 in generating these metabolites.
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