Biomaterial Database

Antimicrobial properties of antiseptic-impregnated biological dressings. 1988

J N Kearney, and T Arain, and K T Holland

Yorkshire Regional Tissue Bank, Pinderfields General Hospital, Wakefield, UK.

Three antiseptics--chlorhexidine acetate, silver nitrate and povidone-iodine--were incorporated into biological dressings (human skin and amnio-chorion) and evaluated in vitro against disparate micro-organisms. Results indicated that antimicrobial levels of chlorhexidine and silver were released from the dressings over a clinically relevant time period, whereas povidone-iodine was ineffective. Chlorhexidine dressings demonstrated broad-spectrum activity, whereas silver dressings were most effective against Pseudomonas aeruginosa.

UI	MeSH Term	Description	Entries
D011206	Povidone-Iodine	An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.	PVP-Iodine,Polyvinylpyrrolidone Iodine,Alphadine,Betadine,Betaisodona,Disadine,Isodine,PVP-I,Pharmadine,Providine,Alphadines,Betadines,Disadines,Isodines,PVP Iodine,PVP-Iodines,Pharmadines,Polyvinylpyrrolidone Iodines,Povidone Iodine,Povidone-Iodines,Providines
D011550	Pseudomonas aeruginosa	A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.	Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D002176	Candida albicans	A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).	Candida albicans var. stellatoidea,Candida stellatoidea,Dematium albicans,Monilia albicans,Myceloblastanon albicans,Mycotorula albicans,Parasaccharomyces albicans,Procandida albicans,Procandida stellatoidea,Saccharomyces albicans,Syringospora albicans
D002710	Chlorhexidine	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	Chlorhexidine Acetate,Chlorhexidine Hydrochloride,MK-412A,Novalsan,Sebidin A,Tubulicid,Acetate, Chlorhexidine,Hydrochloride, Chlorhexidine,MK 412A,MK412A
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000891	Anti-Infective Agents, Local	Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.	Anti-Infective Agents, Topical,Antiseptic,Antiseptics,Microbicides, Local,Microbicides, Topical,Antiinfective Agents, Local,Antiinfective Agents, Topical,Local Anti-Infective Agents,Local Antiinfective Agents,Topical Anti-Infective Agents,Topical Antiinfective Agents,Agents, Local Anti-Infective,Agents, Local Antiinfective,Agents, Topical Anti-Infective,Agents, Topical Antiinfective,Anti Infective Agents, Local,Anti Infective Agents, Topical,Local Anti Infective Agents,Local Microbicides,Topical Anti Infective Agents,Topical Microbicides
D001458	Bandages	Material used for wrapping or binding any part of the body.	Dressings,Bandage,Dressing
D001684	Biological Dressings	Human or animal tissue used as temporary wound coverings.	Allograft Dressings,Amniotic Membrane Dressings,Dressings, Biological,Heterograft Dressings,Homograft Dressings,Pig Skin Dressings,Porcine Xenograft Dressings,Xenograft Dressings,Biologic Dressing,Dressing, Biological,Allograft Dressing,Amniotic Membrane Dressing,Biologic Dressings,Biological Dressing,Dressing, Allograft,Dressing, Amniotic Membrane,Dressing, Biologic,Dressing, Heterograft,Dressing, Homograft,Dressing, Pig Skin,Dressing, Porcine Xenograft,Dressing, Xenograft,Dressings, Allograft,Dressings, Amniotic Membrane,Dressings, Biologic,Dressings, Heterograft,Dressings, Homograft,Dressings, Pig Skin,Dressings, Porcine Xenograft,Dressings, Xenograft,Heterograft Dressing,Homograft Dressing,Pig Skin Dressing,Porcine Xenograft Dressing,Xenograft Dressing,Xenograft Dressing, Porcine,Xenograft Dressings, Porcine
D012835	Silver Nitrate	A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.	Alcoholic Silver Nitrate,Silver Nitrate, Silver (2+) Salt (2:1),Silver Nitrate, Alcoholic
D013211	Staphylococcus aureus	Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.