Biomaterial Database

Urinary excretion of D-glucaric acid in porphyria cutanea tarda. 1987

J C Tutor, and A Lopez-Urrutia, and M P Fernandez

Laboratorio Central, Hospital General de Galicia, Clinico Universitario, Santiago de Compostela, Spain.

Twenty patients with porphyria cutanea tarda who had ingested no alcohol for at least 10 days before sampling were found to possess urinary D-glucaric acid levels similar to those of 30 clinically healthy controls. Correlation between urinary excretion of D-glucaric acid on the one hand and plasma or urinary porphyrin concentrations on the other was not statistically significant. These results suggest that the high urinary concentrations of D-glucaric acid found in porphyria cutanea tarda patients by Budillon et al. (Acta Hepato-Gastroenterol. 25 (1978) 267) may have been due to recent consumption of alcohol rather than to the porphyrin pathology.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011164	Porphyrias	A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.	Porphyria,Porphyrin Disorder,Disorder, Porphyrin,Disorders, Porphyrin,Porphyrin Disorders
D011166	Porphyrins	A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.	Porphyrin
D005723	gamma-Glutamyltransferase	An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.	GGTP,Glutamyl Transpeptidase,gammaglutamyltransferase,gamma-Glutamyl Transpeptidase,Transpeptidase, Glutamyl,Transpeptidase, gamma-Glutamyl,gamma Glutamyl Transpeptidase,gamma Glutamyltransferase
D005937	Glucaric Acid	A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.	Glucosaccharic Acid,L-Gularic Acid,Levo-Gularic Acid,Tetrahydroxyadipic Acid,Calcium Glucarate,Calcium Glucarate, Anhydrous,Calcium Saccharate,Calcium Saccharate Anhydrous,Calcium Saccharate Tetrahydrate,Calcium Saccharate, Anhydrous,D-Glucaric Acid,D-Saccharic Acid,Saccharic Acid,Acid, Saccharic,Anhydrous Calcium Glucarate,Anhydrous Calcium Saccharate,D Glucaric Acid,D Saccharic Acid,Glucarate, Anhydrous Calcium,Glucarate, Calcium,L Gularic Acid,Levo Gularic Acid,Saccharate Tetrahydrate, Calcium,Saccharate, Anhydrous Calcium,Saccharate, Calcium,Tetrahydrate, Calcium Saccharate
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000428	Alcohol Drinking	Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.	Alcohol Consumption,Alcohol Intake,Drinking, Alcohol,Alcohol Drinking Habits,Alcohol Drinking Habit,Alcohol Intakes,Consumption, Alcohol,Drinking Habit, Alcohol,Habit, Alcohol Drinking,Habits, Alcohol Drinking,Intake, Alcohol
D012871	Skin Diseases	Diseases involving the DERMIS or EPIDERMIS.	Dermatoses,Skin and Subcutaneous Tissue Disorders,Dermatosis,Skin Disease
D013400	Sugar Acids	MONOSACCHARIDES and other sugars that contain one or more carboxylic acid moieties.	Acids, Sugar