Anti-anginal efficacy of a controlled-release formulation of isosorbide-5-mononitrate once daily in angina patients on chronic beta-blockade. 1988

A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
Department of Clinical Physiology, Tampere University Central Hospital, Finland.

The anti-anginal effect of a controlled-release (Durules) formulation of isosorbide-5-mononitrate (5-ISMN) 60 mg, Imdur, once daily was evaluated in a randomised double-blind, placebo-controlled, crossover study with a placebo run-in period. Each period lasted for 2 weeks. A total of 70 patients (58 men and 12 women) with stable exertional angina pectoris on beta-blockade, mean age 59 years (range 39-71), were included. Exercise testing was performed on a bicycle ergometer 3 hours after the dose at the end of each period. Anginal attacks and intake of sublingual nitroglycerin tablets were noted. Imdur in combination with a beta-blocker significantly increased the total exercise capacity, the time and total work until the onset of chest pain and at 1 mm ST-depression compared with beta-blockade alone. The attack rate and the nitroglycerin consumption were significantly decreased. Headache was the only significant side-effect. In conclusion, the addition of Imdur once daily to beta-blockade significantly increased the anti-anginal effect.

UI MeSH Term Description Entries
D007548 Isosorbide Dinitrate A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. Cardonit 40,Dilatrate,Iso-Bid,Isodinit,Isoket,Isoket Retard-120,Isomak R,Isordil,Isotrate,Nitrosorbide,Sorbitrate,Sorbonit,Dinitrate, Isosorbide,Iso Bid,IsoBid,Isoket Retard 120,Isoket Retard120
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D005260 Female Females
D005996 Nitroglycerin A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Glyceryl Trinitrate,Anginine,Dynamite,Gilustenon,Nitrangin,Nitro-Bid,Nitro-Dur,Nitrocard,Nitroderm,Nitroderm TTS,Nitroglyn,Nitrol,Nitrolan,Nitrong,Nitrospan,Nitrostat,Perlinganit,Susadrin,Sustac,Sustak,Sustonit,Transderm Nitro,Tridil,Trinitrin,Trinitrolong,Nitro Bid,Nitro Dur,NitroBid,NitroDur,Trinitrate, Glyceryl

Related Publications

A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
January 1987, Drugs,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
October 1998, Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
April 1991, The Canadian journal of cardiology,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
January 1988, European heart journal,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
January 1985, Zeitschrift fur Kardiologie,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
February 1996, International journal of cardiology,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
August 1999, Journal of cardiovascular pharmacology,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
June 1990, Journal of clinical pharmacy and therapeutics,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
June 1997, International journal of cardiology,
A Uusitalo, and O Keyriläinen, and R Härkönen, and P Rautio, and N Rehnqvist, and J Engvall, and U Rosenqvist, and G Nyberg, and A Aberg, and G Ulvenstam
September 1989, Journal of cardiovascular pharmacology,
Copied contents to your clipboard!