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In 38 patients with immunogenic hyperthyroidism a follow-up was performed to estimate the value of TBII before, during and after methimazole therapy. Before therapy increased TBII were detectable in 37 patients (94.4%). After 12 months methimazole therapy 25 patients had TSH-receptor antibodies (66%) within the normal range. In 13 patients positive antibody titres were found. In most cases persistence of increased TBII-values during drug treatment was an indicator of the persistence of active hyperthyroidism (10 of 13 patients). In the rule a disappearance of TBII-activity was combined with a functional remission (22 of 25 patients). Prolonged demonstration of TBII-activity in conjunction with persistence of hyperthyroidism should lead to ablative measures. In contrast to this medical therapy should be finished in patients with immunological and functional remission. Though in the further follow-up a recurrence of the immunological base of the disease with a functional and clinical relapse is possible.
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
January 1987,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
December 1987,
Chirurgia italiana,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
January 1987,
Radiobiologia, radiotherapia,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
December 1983,
Kaku igaku. The Japanese journal of nuclear medicine,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
April 1981,
The Journal of clinical endocrinology and metabolism,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
October 1979,
Nihon Naibunpi Gakkai zasshi,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
October 1979,
Nihon Naibunpi Gakkai zasshi,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
September 1983,
Kaku igaku. The Japanese journal of nuclear medicine,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
January 1989,
Acta medica Hungarica,
H J Heberling, and
B Bierwolf, and
E Kuhlmann, and
T Klugmann, and
P Dietel, and
S Fischer
January 1983,
Acta endocrinologica. Supplementum,
