-transparent.png){kind=logo}
Of 32 patients exposed to a single batch of factor VIII contaminated with human immunodeficiency virus (HIV), 18 became antibody positive. Serial T cell subset analyses over the succeeding four years have shown a progressive decline in circulating T4 cells in those 18 but no change in the 14 who remain seronegative. 2 of the seroconverters have died and a further 7 have symptoms attributable to HIV infection. In the group as a whole, the HLA haplotype A1 B8 DR3 was weakly associated with an increased risk of seroconversion on exposure to the virus while, in those who seroconverted, it was strongly associated with a rapid decline in T4 cells and development of HIV-related symptoms within four years of infection.
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
July 2003,
Tissue antigens,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
January 2013,
Case reports in otolaryngology,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
January 1996,
Experimental and clinical immunogenetics,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
April 1997,
Immunological investigations,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
May 2006,
Diabetes,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
May 2010,
Leukemia,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
February 2009,
Diabetes, obesity & metabolism,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
March 1998,
Blood,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
January 2010,
Journal of clinical immunology,
C M Steel, and
C A Ludlam, and
D Beatson, and
J F Peutherer, and
R J Cuthbert, and
P Simmonds, and
H Morrison, and
M Jones
January 1996,
Immunogenetics,
