BIOMAT Database Logo BIOMAT Database Logo

Clinical findings, pathological changes and endocrinological secretory patterns in mares with ovarian tumours. 1979

G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely

The clinical, structural and functional characteristics of ovarian tumours were studied in 10 mares. Proliferation of the granulosa cells of large and small follicles and the presence of various numbers of Leydig-like cells in the theca interna were the predominant microscopic findings in 9 of the mares. All 9 of these animals had higher than normal (P less than 0.005) concentrations of testosterone in the peripheral plasma; 2 animals which exhibited male behaviour had testosterone concentrations greater than 100 pg/ml and the largest number of Leydig-like cells in the theca. Mares with lower testosterone concentrations (7/9) exhibited anoestrus or intermittent oestrous behaviour. The predominant microscopic changes in the other mare involved the proliferation of Sertoli-like cells; oestrogen concentrations were highest in this mare. Testosterone values were normal when no Leydig-like cells were observed in the theca. The unaffected ovary of all 10 mares was small and inactive. Eight mares resumed normal cyclic ovarian activity between 115 and 393 days after the removal of the affected ovary.

UI MeSH Term Description Entries
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D005260 Female Females
D006106 Granulosa Cell Tumor A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES. Cancer of Granulosa Cells,Granulosa Cell Cancer,Cancer, Granulosa Cell,Cancers, Granulosa Cell,Cell Cancer, Granulosa,Cell Cancers, Granulosa,Cells Cancer, Granulosa,Cells Cancers, Granulosa,Granulosa Cell Cancers,Granulosa Cell Tumors,Granulosa Cells Cancer,Granulosa Cells Cancers,Tumor, Granulosa Cell,Tumors, Granulosa Cell
D006734 Horse Diseases Diseases of domestic and wild horses of the species Equus caballus. Equine Diseases,Disease, Equine,Disease, Horse,Diseases, Equine,Diseases, Horse,Equine Disease,Horse Disease
D006736 Horses Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest. Equus caballus,Equus przewalskii,Horse, Domestic,Domestic Horse,Domestic Horses,Horse,Horses, Domestic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D013739 Testosterone A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. 17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone

Related Publications

G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Steroid hormone secretory patterns in mares with granulosa cell tumours.
August 1987, Zentralblatt fur Veterinarmedizin. Reihe A,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
[Clinical and endocrinological findings of bitches with ovarian cyst syndrome].
October 2013, Schweizer Archiv fur Tierheilkunde,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Ovarian tumours: clinical and pathological features.
April 1976, Clinics in obstetrics and gynaecology,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Clinical and pathological patterns of non-epithelial malignant ovarian tumours in Western Saudi Arabia.
January 2022, The Nigerian postgraduate medical journal,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Endocrinological findings in two patients with premature ovarian failure.
January 1971, Lancet (London, England),
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Pathological study of ovarian tumours.
February 1962, Journal of the Indian Medical Association,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Two cases of bovine male pseudohermaphrodites with different endocrinological and pathological findings.
April 2010, The Journal of veterinary medical science,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Cytogenetic and clinical findings in mares with gonadal dysgenesis.
January 1979, Journal of reproduction and fertility. Supplement,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Endocrinological and clinical analysis of hyperprolactinemic patients with and without ultrasonically diagnosed polycystic ovarian changes.
January 1997, Gynecologic and obstetric investigation,
G H Stabenfeldt, and J P Hughes, and P C Kennedy, and D M Meagher, and D P Neely
Ovarian changes during gestation in pony mares.
July 1974, Equine veterinary journal,
Copied contents to your clipboard!