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The concentrations of the primary prostaglandins (PG) F-2alpha and E-2 and the metabolite 13,14-dihydro-15-oxo-prostaglandin (PGFM) in maternal and fetal plasma and in allantoic fluid were measured in chronically catheterized mares and fetuses. A gradual rise in all 3 PGs occurred with increasing gestational age. PGE-2 and PGF-2 alpha levels were highest in the allantoic fluid and lowest in the maternal plasma, whereas PGFM concentrations were greatest in maternal plasma. Significant venous-arterial plasma differences in PGFM concentration were detected across the uterine circulation between 180 and 280 days gestation. The 3--5-fold rise in maternal PGFM associated with fasting or intrauterine surgery was virtually abolished by meclofenamic acid, a prostaglandin synthetase inhibitor. Increases in PGE-2 and PGF-2 alpha in the fetal fluids preceded premature delivery of the foal, while PG changes in maternal plasma were minimal even 10--20 h before delivery.
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
January 1995,
American journal of obstetrics and gynecology,
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
April 2005,
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M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
September 1977,
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M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
July 2015,
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians,
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
July 1984,
American journal of obstetrics and gynecology,
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
September 1979,
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M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
August 1997,
Biology of reproduction,
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
December 1970,
Journal of reproduction and fertility,
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
May 1989,
Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics,
M Silver, and
R J Barnes, and
R S Comline, and
A L Fowden, and
L Clover, and
M D Mitchell
January 1982,
Comparative biochemistry and physiology. A, Comparative physiology,
