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Atrial natriuretic peptide (ANP) has been demonstrated to exert endocrine functions, including the modulation of steroid synthesis. This prompted investigations to search for ANP receptors in the corpus luteum, a tissue that produces progesterone. The studies revealed a single binding site for [125I] ANP with similar characteristics (Kd, 122 pM; maximum binding, 18 fmol/mg protein) in all four stages of corpus luteum development. These receptors were demonstrated to stimulate cGMP production upon activation with synthetic ANP. Maximal cGMP synthesis was observed at 10(-7) M ANP, 5 min after activation of receptors. An acidic extract of corpus luteum contained immunoreactive ANP (approximately 220 fmol/g tissue), as indicated by gel chromatography, HPLC, and identification by means of a highly specific ANP antibody. The data do not permit definition of a specific endocrine role of ANP in the corpus luteum.
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
May 1996,
Theriogenology,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
March 1990,
The Journal of endocrinology,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
August 1995,
The American journal of physiology,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
July 1974,
Journal of lipid research,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
January 1965,
Steroids,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
November 1975,
Biology of reproduction,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
February 2001,
Reproduction (Cambridge, England),
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
May 1996,
Theriogenology,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
October 1984,
Theriogenology,
A M Vollmar, and
C Mytzka, and
R M Arendt, and
R Schulz
August 2000,
Investigative ophthalmology & visual science,
