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Aggregation of inhaled 239PuO2 particles in the pulmonary region of the lung may be required for promotion of pulmonary carcinogenesis in rats. Female Wistar rats were exposed to an aerosol of 239PuO2 and their lungs examined by scanning electron microscopic (SEM) autoradiography. SEM autoradiography provides a rapid and inexpensive method for viewing a large lung tissue volume for alpha tracks. Evidence of particle aggregation was seen by 28 days postinhalation and was marked by 90 to 150 days post-inhalation. Subpleural plutonium particles resulted in exposure into the pleural cavity. Peribronchiolar, alveolar plutonium particles and particle aggregates gave the greatest radiation dose to the bronchiolar epithelium. High-dose, overlapping, alpha-track, radiation zones in bronchiolar epithelium may be required for maximum development of lung tumors.
C L Sanders, and
K E McDonald, and
K E Lauhala
November 2012,
Radiation research,
C L Sanders, and
K E McDonald, and
K E Lauhala
January 1970,
BNWL [reports]. U.S. Atomic Energy Commission,
C L Sanders, and
K E McDonald, and
K E Lauhala
May 1968,
BNWL [reports]. U.S. Atomic Energy Commission,
C L Sanders, and
K E McDonald, and
K E Lauhala
February 1977,
Health physics,
C L Sanders, and
K E McDonald, and
K E Lauhala
January 1979,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
C L Sanders, and
K E McDonald, and
K E Lauhala
January 1970,
BNWL [reports]. U.S. Atomic Energy Commission,
C L Sanders, and
K E McDonald, and
K E Lauhala
May 1968,
BNWL [reports]. U.S. Atomic Energy Commission,
C L Sanders, and
K E McDonald, and
K E Lauhala
May 1982,
Health physics,
C L Sanders, and
K E McDonald, and
K E Lauhala
August 1989,
International journal of radiation biology,
C L Sanders, and
K E McDonald, and
K E Lauhala
January 1970,
BNWL [reports]. U.S. Atomic Energy Commission,
