-transparent.png){kind=logo}
The effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5-40 microM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P less than 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 +/- 0.11 microM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10-100 microM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+-Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
February 1966,
Die Naturwissenschaften,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
October 1992,
Molecular and cellular biochemistry,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
July 1999,
Journal of molecular and cellular cardiology,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
December 1983,
Biochemistry,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
August 1976,
Biochemical medicine,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
October 1969,
The Biochemical journal,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
August 1976,
European journal of biochemistry,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
July 2001,
Biochemical and biophysical research communications,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
November 1980,
FEBS letters,
A R Baydoun, and
A Markham, and
R M Morgan, and
A J Sweetman
June 1980,
The Biochemical journal,
