BIOMAT Database Logo BIOMAT Database Logo

Time-dependence and differential induction of rat and guinea pig peroxisomal beta-oxidation, palmitoyl-CoA hydrolase, cytosolic and microsomal epoxide hydrolase after treatment with hypolipidemic drugs. 1988

F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Institut für Toxikologie, Universität Mainz, Federal Republic of Germany.

Fischer-344 rats and Hartley guinea pigs received a diet containing 0.01% (w/w), 0.05% (w/w), or 0.25% (w/w) of the hypolipidemic drug fenofibrate. Rats were treated for 4, 7, 14, or 21 days, and a clear dose-dependent and weak time-dependent increase in liver/body weight ratio was observed. The specific activity of peroxisomal beta-oxidation increased linearly with time at all concentrations used. A dose-dependent increase in cEH was observed, but the activity remained constant after treatment for 7 days. Enhancement of palmitoyl-CoA hydrolase was dose-dependent, but was similar at all 4 time points investigated. In contrast to the other enzyme activities, mEH was not or only minimally (less than 1.5-fold) induced. In contrast to the rat, treatment of guinea pigs with fenofibrate for 1 week did not change liver weight or enzyme activities. Prolonged treatment of guinea pigs (4 weeks) with fenofibrate did not result in an increase in enzyme activities. This was also observed with clofibrate whereas tiadenol caused a slight increase in enzyme activities (1.5- to 2.6-fold). In contrast to the guinea pig each of the three hypolipidemic drugs led to an increase in enzyme activities in the rat liver after treatment for 1 week.

UI MeSH Term Description Entries
D008297 Male Males
D008830 Microbodies Electron-dense cytoplasmic particles bounded by a single membrane, such as PEROXISOMES; GLYOXYSOMES; and glycosomes. Glycosomes,Glycosome,Microbody
D008861 Microsomes Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) Microsome
D010170 Palmitoyl-CoA Hydrolase Enzyme catalyzing reversibly the hydrolysis of palmitoyl-CoA or other long-chain acyl coenzyme A compounds to yield CoA and palmitate or other acyl esters. The enzyme is involved in the esterification of fatty acids to form triglycerides. EC 3.1.2.2. Acyl CoA Hydrolase,Fatty Acyl Thioesterase,Palmitoyl CoA Deacylase,Palmitoyl Coenzyme A Hydrolase,Palmitoyl Thioesterase,Long-Chain Fatty-Acyl-CoA Hydrolase,Oleoyl-CoA Acylhydrolase,Stearoyl CoA Hydrolase,Thioesterase I,Acylhydrolase, Oleoyl-CoA,CoA Deacylase, Palmitoyl,CoA Hydrolase, Acyl,CoA Hydrolase, Stearoyl,Deacylase, Palmitoyl CoA,Fatty-Acyl-CoA Hydrolase, Long-Chain,Hydrolase, Acyl CoA,Hydrolase, Long-Chain Fatty-Acyl-CoA,Hydrolase, Palmitoyl-CoA,Hydrolase, Stearoyl CoA,Long Chain Fatty Acyl CoA Hydrolase,Oleoyl CoA Acylhydrolase,Palmitoyl CoA Hydrolase,Thioesterase, Fatty Acyl,Thioesterase, Palmitoyl
D011916 Rats, Inbred F344 An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. Fischer Rats,Rats, Inbred CDF,Rats, Inbred Fischer 344,Rats, F344,Rats, Inbred Fisher 344,CDF Rat, Inbred,CDF Rats, Inbred,F344 Rat,F344 Rat, Inbred,F344 Rats,F344 Rats, Inbred,Inbred CDF Rat,Inbred CDF Rats,Inbred F344 Rat,Inbred F344 Rats,Rat, F344,Rat, Inbred CDF,Rat, Inbred F344,Rats, Fischer
D003600 Cytosol Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. Cytosols
D004790 Enzyme Induction An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis. Induction, Enzyme
D004851 Epoxide Hydrolases Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively. Epoxide Hydrase,Epoxide Hydrases,Epoxide Hydratase,Epoxide Hydratases,Epoxide Hydrolase,9,10-Epoxypalmitic Acid Hydrase,Microsomal Epoxide Hydrolase,Styrene Epoxide Hydrolase,9,10 Epoxypalmitic Acid Hydrase,Acid Hydrase, 9,10-Epoxypalmitic,Epoxide Hydrolase, Microsomal,Epoxide Hydrolase, Styrene,Hydrase, 9,10-Epoxypalmitic Acid,Hydrase, Epoxide,Hydrases, Epoxide,Hydratase, Epoxide,Hydratases, Epoxide,Hydrolase, Epoxide,Hydrolase, Microsomal Epoxide,Hydrolase, Styrene Epoxide,Hydrolases, Epoxide
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Coordinate induction of peroxisomal beta-oxidation activity and cytosolic epoxide hydrolase activity.
January 1987, Pharmacology & therapeutics,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities.
November 1983, Toxicology and applied pharmacology,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Different induction of microsomal carboxylesterases, palmitoyl-CoA hydrolase and acyl-L-carnitine hydrolase in rat liver after treatment with clofibrate.
August 1986, Biochemical pharmacology,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Peroxisomal palmitoyl-CoA oxidation in the Zucker rat.
June 1983, The Biochemical journal,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Effect of choline-deficiency and methotrexate administration on peroxisomal beta-oxidation, palmitoyl-CoA hydrolase activity and the glutathione content in rat liver.
April 1988, Carcinogenesis,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Induction of peroxisomal enzymes and palmitoyl-CoA hydrolase in rats treated with cholestyramine and nicotinic acid.
October 1984, Biochemical pharmacology,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Microsomal and cytosolic epoxide hydrolases, the peroxisomal fatty acid beta-oxidation system and catalase. Activities, distribution and induction in rat liver parenchymal and non-parenchymal cells.
September 1988, European journal of biochemistry,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Rapid stimulation of liver palmitoyl-CoA synthetase, carnitine palmitoyltransferase and glycerophosphate acyltransferase compared to peroxisomal beta-oxidation and palmitoyl-CoA hydrolase in rats fed high-fat diets.
June 1988, Biochimica et biophysica acta,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Microsomal and cytosolic epoxide hydrolase in Drosophila melanogaster.
July 1986, Biochemical pharmacology,
F Oesch, and R Hartmann, and C Timms, and M Strolin-Benedetti, and P Dostert, and W Wörner, and L Schladt
Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase).
February 1996, The Biochemical journal,
Copied contents to your clipboard!