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We concluded that a neutral subfraction of mannan from bakers' yeast (Saccharomyces cerevisiae wild type strain), abbreviated as WNM, was able to induce the release of leukotrienes from mouse peritoneal macrophages (M phi). The culture supernatant fluid of M phi from normal mice cultured with WNM caused a marked contraction of guinea pig ileum. This activity was inhibited by pretreatment of M phi with inhibitor of phospholipase A2 or lipoxygenase before M phi were treated with WNM, and by treatment of the incubation bath with a slow reacting substance antagonist, FPL55712. On the other hand, pretreatment of M phi with a cyclooxygenase inhibitor potentiated contractile response of ileum by culture supernatant fluid of M phi. A high performance liquid chromatographic analysis of a culture supernatant fluid of M phi treated with WNM demonstrated the presence of leukotrienes C4 and D4, and their related compounds.
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
January 1984,
Microbiology and immunology,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
May 1998,
Yao xue xue bao = Acta pharmaceutica Sinica,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
September 1983,
Journal of pharmacobio-dynamics,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
December 1991,
Lipids,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
August 1986,
Pharmacological research communications,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
November 1981,
Archives of biochemistry and biophysics,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
February 2022,
Environmental science and pollution research international,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
July 1984,
Journal of pharmacobio-dynamics,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
September 1987,
The Journal of biological chemistry,
K Ishitani, and
M Harakawa, and
T Mikami, and
T Nagase, and
S Suzuki, and
M Suzuki
March 1987,
Chemical & pharmaceutical bulletin,
