Biomaterial Database

Sodium cotransport systems in epithelial secretion. 1988

R K Kinne

Max-Planck-Institut fuer Systemphysiologie, Dortmund, FRG.

1. After considering the direct coupling and indirect coupling to the sodium gradient in sodium-dependent secretion across epithelia, the properties of the Na-K-Cl cotransporter involved in active chloride secretion and active chloride absorption are summarized. 2. A comparison between cellular mechanism of secretion and absorption shows that the direction of transepithelial transport is determined mainly by the intracellular localization of sodium cotransport systems and sodium-independent leaks. 3. Sodium cotransport systems, performing a similar function in various epithelia or species, may provide a powerful model to study their function at a molecular level.

UI	MeSH Term	Description	Entries
D004848	Epithelium	The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body.	Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001692	Biological Transport	The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.	Transport, Biological,Biologic Transport,Transport, Biologic
D001717	Birds	Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.	Aves,Bird
D012754	Sharks	A group of elongate elasmobranchs. Sharks are mostly marine fish, with certain species large and voracious.	Shark
D015222	Sodium Channels	Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.	Ion Channels, Sodium,Ion Channel, Sodium,Sodium Channel,Sodium Ion Channels,Channel, Sodium,Channel, Sodium Ion,Channels, Sodium,Channels, Sodium Ion,Sodium Ion Channel