New aspects of metabolic conjugation of chloramphenicol. 1988

J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
Laboratoire des Xénobiotiques, I.N.R.A., Toulouse, France.

New and major chloramphenicol (CP) metabolites have been isolated from the urine of goats administered [3H]CP. The CP-3-sulfoconjugate has been identified formally from its chromatographic behaviour and mass spectrometric analysis, as well as from incubations of CP with liver cytosol, using synthetic CP-conjugate as reference. Only a strong assumption is made of the identity of the CP-3-phosphoconjugate.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D010710 Phosphates Inorganic salts of phosphoric acid. Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D002701 Chloramphenicol An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) Cloranfenicol,Kloramfenikol,Levomycetin,Amphenicol,Amphenicols,Chlornitromycin,Chlorocid,Chloromycetin,Detreomycin,Ophthochlor,Syntomycin
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D002852 Chromatography, Ion Exchange Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins. Chromatography, Ion-Exchange,Ion-Exchange Chromatography,Chromatographies, Ion Exchange,Chromatographies, Ion-Exchange,Ion Exchange Chromatographies,Ion Exchange Chromatography,Ion-Exchange Chromatographies
D003600 Cytosol Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. Cytosols
D006041 Goats Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP. Capra,Capras,Goat
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013431 Sulfates Inorganic salts of sulfuric acid. Sulfate,Sulfates, Inorganic,Inorganic Sulfates
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
December 2004, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
January 1977, Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
January 1994, Drug metabolism and disposition: the biological fate of chemicals,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
October 1974, Postgraduate medical journal,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
January 1976, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
January 1976, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
January 1970, Acta microbiologica Polonica. Series A: Microbiologia generalis,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
January 1954, Archivio di patologia e clinica medica,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
November 1978, Strahlentherapie,
J M Wal, and J C Peleran, and E Perdu, and D Rao, and G Bories
July 2014, Nucleic acids research,
Copied contents to your clipboard!