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p16(INK4A) expression in invasive laryngeal cancer. 2016
Brenda Y Hernandez, and
Mobeen Rahman, and
Charles F Lynch, and
Wendy Cozen, and
Elizabeth R Unger, and
Martin Steinau, and
Trevor Thompson, and
Maria Sibug Saber, and
Sean F Altekruse, and
Marc T Goodman, and
Amy Powers, and
Christopher Lyu, and
Mona Saraiya
University of Hawaii Cancer Center, 701 Ilalo Street #239, Honolulu, Hawaii, USA 96813.
We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA. Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively. Positivity for p16 and/or HPV DNA was not associated with 5-year survival (log-rank p value= 0.55). Our findings support a limited role of HPV in laryngeal carcinogenesis. p16 is not a reliable surrogate for HPV status in laryngeal cancers and is not a predictor of laryngeal cancer survival.
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