-transparent.png){kind=logo}
Five chromosome 10 DNA markers (D10S1, D10S3, D10S4, D10S5, and RBP3) were typed in five large pedigrees with multiple endocrine neoplasia type 2A (MEN-2A) and in five non-MEN-2A pedigrees. Linkage analyses showed that these loci and the locus for MEN-2A (MEN2A) are in one linkage group spanning at least 70 cM. The order of the marker loci is RBP3-D10S5-D10S3-D10S1-D10S4, with interlocus recombination frequencies of 7, 13-19, 19, and 19%, respectively, all on the same side of MEN2A. Analyses of sex-specific recombination frequencies indicated no significant differences between males and females for any of the map intervals studied. Previous localization of D10S5 and RBP3 to the proximal region of the long arm and the pericentric region, respectively, comparison of results with other studies, and our preliminary results with other chromosome 10 markers suggest that the D10S4 end of the map extends into the long arm. Our linkage map has been constructed using only two- and three-locus analyses. It will be possible to combine our results with those of other groups to construct a more detailed and accurate genetic map of chromosome 10.
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
September 1994,
Mammalian genome : official journal of the International Mammalian Genome Society,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
August 1990,
Proceedings of the National Academy of Sciences of the United States of America,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
November 1988,
Genomics,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
January 1993,
Cytogenetics and cell genetics,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
November 1990,
Genomics,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
May 1994,
Genomics,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
February 1992,
Nature,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
November 1989,
Genomics,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
November 1987,
Proceedings of the National Academy of Sciences of the United States of America,
L A Farrer, and
C M Castiglione, and
J R Kidd, and
S Myers, and
N Carson, and
N E Simpson, and
K K Kidd
June 1993,
Diabetes,
