FDM 3D printing of modified drug-delivery systems using hot melt extrusion: a new approach for individualized therapy. 2017

Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
Laboratory of Food, Drug & Cosmetics (LTMAC), School of Health Sciences, University of Brasília (UnB), 70.910-900, Brasília, DF, Brazil.

The production process of 3D-printed drugs offers unique advantages such as the possibility of individualizing the drug therapy and easily associating different drugs and release technologies in the same pharmaceutical unit. Fused deposition modeling, a 3D printing technique, seems especially interesting for pharmaceutical applications, due to its low cost, precise and reproducible control of the printed structures, and versatility for industrial and laboratory scale. This technique combined with another technology already adapted for the pharmaceutical industry, the hot melt extrusion, is able to incorporate various mechanisms of modified drug release. This special report aims to bring together data of the experimental progress achieved using the fused deposition modeling 3D printing combined with hot melt extrusion technique and its potential in drug delivery. [Formula: see text].

UI MeSH Term Description Entries
D011108 Polymers Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS). Polymer
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D006358 Hot Temperature Presence of warmth or heat or a temperature notably higher than an accustomed norm. Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D013678 Technology, Pharmaceutical The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients. Technology, Pharmacy,Pharmaceutic Technology,Pharmaceutical Technology,Pharmacy Technology,Technology, Pharmaceutic
D049329 Nanostructures Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES. Nanomaterials,Nanostructured Materials,Material, Nanostructured,Materials, Nanostructured,Nanomaterial,Nanostructure,Nanostructured Material
D057285 Precision Medicine Clinical, therapeutic and diagnostic approaches to optimal disease management based on individual variations in a patient's genetic profile. Individualized Medicine,Predictive Medicine,P Health,P-Health,Personalized Medicine,Theranostics,Medicine, Individualized,Medicine, Personalized,Medicine, Precision,Medicine, Predictive,Theranostic
D066330 Printing, Three-Dimensional Process for making, building or constructing a physical object from a three-dimensional digital model by laying down many successive thin layers of building material. 3-D Printing,3-Dimensional Printing,3D Printing,Three-Dimensional Printing,3 D Printing,3 Dimensional Printing,3-D Printings,3-Dimensional Printings,3D Printings,Printing, 3-D,Printing, 3-Dimensional,Printing, 3D,Printing, Three Dimensional,Printings, 3-D,Printings, 3-Dimensional,Printings, 3D,Printings, Three-Dimensional,Three Dimensional Printing,Three-Dimensional Printings

Related Publications

Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
October 2018, Pharmaceutics,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
May 2021, International journal of pharmaceutics,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
October 2019, Additive manufacturing,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
September 2025, AAPS PharmSciTech,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
December 2008, Expert opinion on drug delivery,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
October 2023, AAPS PharmSciTech,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
November 2018, International journal of pharmaceutics,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
February 2007, Journal of pharmaceutical sciences,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
February 2023, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
Marcilio Cunha-Filho, and Maísa Rp Araújo, and Guilherme M Gelfuso, and Tais Gratieri
January 2020, Pharmaceutics,
Copied contents to your clipboard!