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Amino acid concentrations were measured in CSF samples obtained by lumbar puncture in 51 patients, cervical puncture in 16 patients, spinal drains in nine patients, ventricular taps in five patients and from below a spinal block in six patients. There was evidence of a rostrocaudal gradient for GABA and taurine and a reverse gradient for alanine and asparagine. Lumbar CSF glycine concentrations rose with increasing age whilst GABA concentrations fell. Women had significantly lower concentrations of asparagine and glutamine and elevated taurine compared to men. The influence of biological factors and gradients must be taken into account before the interpretation of changes in CSF amino acid concentrations.
P M Crawford, and
K G Lloyd, and
D W Chadwick
September 1994,
Neuroscience letters,
P M Crawford, and
K G Lloyd, and
D W Chadwick
September 1987,
Nihon rinsho. Japanese journal of clinical medicine,
P M Crawford, and
K G Lloyd, and
D W Chadwick
January 1981,
Advances in biochemical psychopharmacology,
P M Crawford, and
K G Lloyd, and
D W Chadwick
June 1992,
Kidney international. Supplement,
P M Crawford, and
K G Lloyd, and
D W Chadwick
August 1981,
Molecular and cellular biochemistry,
P M Crawford, and
K G Lloyd, and
D W Chadwick
October 1989,
Biological psychiatry,
P M Crawford, and
K G Lloyd, and
D W Chadwick
November 1994,
Alcohol and alcoholism (Oxford, Oxfordshire),
P M Crawford, and
K G Lloyd, and
D W Chadwick
January 1999,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
P M Crawford, and
K G Lloyd, and
D W Chadwick
January 1986,
Advances in neurology,
P M Crawford, and
K G Lloyd, and
D W Chadwick
March 1975,
Journal of neurochemistry,
