BIOMAT Database Logo BIOMAT Database Logo

Assessment of intragastric acidity in man: modern aspects, reproducibility of intragastric pH-monitoring, and pharmacodynamic results obtained with H2-receptor antagonists. 1988

H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Dept. of Gastroenterology, University Hospital, Inselspital Bern, Switzerland.

Unlike other methods for assessing intragastric pH or total acid output, the reproducibility of ambulatory pH-monitoring is excellent but is critically dependent on the electrode system and the recording device. In three double-blind randomized studies in normal volunteers the effects of different dosage regimens of roxatidine acetate were compared with placebo and ranitidine. Roxatidine acetate, 75 mg twice daily, raised median 24-h gastric pH from 1.6 to 3.2 and median nocturnal pH from 1.5 to 3.0 Roxatidine acetate, 150 mg at bedtime, raised median 24-h pH to 2.4 and nocturnal pH to 5.9. Roxatidine acetate, 150 mg at bedtime, was as effective as ranitidine, 300 mg at night, in raising median nocturnal pH. However, when drugs were taken after the evening meal, 150 mg roxatidine acetate was less potent than 300 mg ranitidine or 300 mg roxatidine acetate.

UI MeSH Term Description Entries
D008297 Male Males
D008991 Monitoring, Physiologic The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine. Patient Monitoring,Monitoring, Physiological,Physiologic Monitoring,Monitoring, Patient,Physiological Monitoring
D010880 Piperidines A family of hexahydropyridines.
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D011899 Ranitidine A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. AH-19065,Biotidin,N (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine,Ranisen,Ranitidin,Ranitidine Hydrochloride,Sostril,Zantac,Zantic,AH 19065,AH19065,Hydrochloride, Ranitidine
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D005260 Female Females
D005745 Gastric Acidity Determination Gastric analysis for determination of free acid or total acid. Acidity Determination, Gastric,Acidity Determinations, Gastric,Determination, Gastric Acidity,Determinations, Gastric Acidity,Gastric Acidity Determinations

Related Publications

H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Assessment of intragastric acidity in man: modern aspects and reproducibility of intragastric pH monitoring.
March 1989, The Netherlands journal of medicine,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
[H2 receptor antagonists and intragastric acidity].
November 1984, Deutsche medizinische Wochenschrift (1946),
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
H2-receptor antagonists: intragastric acidity after repeated doses. Introduction.
January 1990, Alimentary pharmacology & therapeutics,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Does smoking interfere with the effect of histamine H2-receptor antagonists on intragastric acidity in man?
May 1987, Gut,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Tolerance and rebound to H2-receptor antagonists: intragastric acidity in patients with duodenal ulcer.
December 1991, Digestive diseases and sciences,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Reproducibility of ambulatory intragastric pH monitoring.
October 1993, The Netherlands journal of medicine,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Once and twice daily doses of H2 antagonists revisited, using continuous intragastric pH monitoring.
May 1988, Scandinavian journal of gastroenterology,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
The effect of H2 receptor antagonists on intragastric pH in critically ill patients.
January 1989, Intensive care medicine,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
Do anticholinergics interact with histamine H2 receptor antagonists on night intragastric acidity in active duodenal ulcer patients?
December 1988, The American journal of gastroenterology,
H S Merki, and L Witzel, and D Kaufmann, and M Kempf, and V Muessig, and J Neumann, and E Scheurle, and J Roehmel, and R P Walt
[Clinical results of intragastric pH measurement. II. Fasting acidity].
January 1955, Zeitschrift fur klinische Medizin,
Copied contents to your clipboard!