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Versatile palladium-catalyzed double carbonylation of aryl bromides. 2017

Chaoren Shen, and Cornel Fink, and Gabor Laurenczy, and Paul J Dyson, and Xiao-Feng Wu
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany. xiao-feng.wu@catalysis.de.

A versatile palladium-catalyzed double carbonylation of aryl bromides has been developed. Using Pd(OAc)2/BuPAd2 as the catalyst system and DBU as the base, under relatively low CO pressure, various α-ketoamides were produced in good yields. In order to get insight into the reaction pathway, real time NMR studies were performed as well and a correlated reaction mechanism is been given.

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