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The effects of intracameral (i.c.) administration of MIF-I on the ocular response to alpha-MSH were tested in rabbits. In confirmation of previous studies, i.c. alpha-MSH significantly increased intraocular pressure (IOP) and reduced pupillary diameter (PD). Concomitant administration of alpha-MSH and MIF-I antagonized both the IOP increase and miosis induced by alpha-MSH. Aqueous humor (AH) dynamics studies revealed that alpha-MSH increases IOP, possibly, by decreasing AH outflow. The decreased AH outflow induced by alpha-MSH was antagonized by concurrent administration of MIF-I and alpha-MSH. MIF-I did not affect IOP or PD when administered alone. These results add more support for a role of alpha-MSH in ocular function, and suggest that the ocular response to alpha-MSH may be subject to inhibitory control by MIF-I.
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
December 1985,
Neuropeptides,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
March 2006,
European journal of pharmacology,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
January 1982,
Peptides,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
September 1973,
Nature: New biology,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
January 1982,
Peptides,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
January 1976,
Pharmacology, biochemistry, and behavior,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
April 1978,
Brain research,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
January 1981,
Peptides,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
January 1986,
Vojnosanitetski pregled,
R K McCullen, and
R L Peiffer, and
L Jennes, and
D E Hernandez
July 1980,
Pharmacology, biochemistry, and behavior,
