-transparent.png){kind=logo}
Thyroid stimulating antibodies (TSAb) and TSH-binding inhibitor immunoglobulins (TBII) were assessed in 30 patients with euthyroid Graves' disease. TSAb were detected in 24 cases (80.0%), the incidence being not significantly different from that in hyperthyroid Graves' disease (29/30, 97.6%). On the other hand, the incidence of TBII in patients with euthyroid Graves' disease (12/30, 40.0%) was significantly lower than that in patients with hyperthyroid Graves' disease (30/30, 100.0%). The mean TSAb and TBII activities in the euthyroid patients were significantly lower than in the hyperthyroid patients (P less than 0.005 and P less than 0.001, respectively). Both TBII and, more closely, TSAb activities correlated with T3-nonsuppressibility and inhibition of serum TSH response to TRH stimulation. The findings supported the stimulation in vivo of the thyroid by these antibodies. Both antithyroglobulin and antimicrosomal antibody titres in euthyroid Graves' disease were significantly lower than in hyperthyroid Graves' disease (P less than 0.05, P less than 0.01, respectively). Goitre size was significantly smaller (P less than 0.001), and 99mTc thyroid uptake was significantly lower (P less than 0.001) in the euthyroid than in the hyperthyroid group. Thus, the reduced mass of thyroid tissues responding to the stimulators was considered to be one of the factors responsible for the euthyroidism despite the presence of TSAb. The high incidence of TSAb and relatively low incidence of TBII in euthyroid Graves' disease indicate that the presence of TSAb does not necessarily lead to hyperthyroidism and that the development of overt thyrotoxicosis may require augmentation of both TSAb and TBII.
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
May 1995,
Clinical endocrinology,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
July 1971,
Lancet (London, England),
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
July 1983,
Clinical endocrinology,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
June 1982,
Acta endocrinologica,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
January 1983,
Acta endocrinologica,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
January 2015,
Internal medicine (Tokyo, Japan),
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
February 1984,
Clinical endocrinology,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
March 2000,
Clinical endocrinology,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
May 1972,
The Journal of the Association of Physicians of India,
K Kasagi, and
H Hatabu, and
Y Tokuda, and
Y Iida, and
K Endo, and
J Konishi
January 1993,
Ryoikibetsu shokogun shirizu,
