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To determine whether human calcitonin inhibits GH secretion in man, as has been described for salmon calcitonin, the effect of an i.v. bolus of human calcitonin or saline on GH release after either insulin-induced hypoglycaemia or the administration of GH-releasing hormone (GHRH) or saline was studied. After the injection of calcitonin, no spontaneous GH surges were seen; the GH response to hypoglycaemia was diminished and the response to GHRH almost completely suppressed. Administration of calcitonin also caused a small and transient rise in plasma PRL and TSH but not LH levels, and no change in the integrated PRL or TSH response. Calcium and magnesium levels did not change. It is concluded that human calcitonin suppresses GH secretion in man, but not by suppressing GHRH and probably not by increasing somatostatin release. In addition, calcitonin has limited PRL and TSH-releasing activity.
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
August 1978,
Metabolism: clinical and experimental,
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
November 1978,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
July 1973,
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B J Looij, and
F Roelfsema, and
D van der Heide, and
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A C Nieuwenhuijzen Kruseman
July 1974,
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B J Looij, and
F Roelfsema, and
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M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
February 1996,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
September 1970,
The Journal of clinical endocrinology and metabolism,
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
July 1974,
The Journal of clinical endocrinology and metabolism,
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
October 1982,
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B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
October 1975,
Experientia,
B J Looij, and
F Roelfsema, and
D van der Heide, and
M Frölich, and
J H Souverijn, and
A C Nieuwenhuijzen Kruseman
October 1983,
Archives of general psychiatry,
