-transparent.png){kind=logo}
1. The role of putative neurotransmitters was investigated in morphine-induced Straub reaction (SR) in albino mice. 2. Apomorphine (15 mg/kg) was also effective in inducing SR. However, in a smaller dose (0.2 mg/kg) it blocked SR induced by morphine. 3. Morphine-induced SR was potentiated by tranylcypromine, reserpine (acute effect), imipramine and L-dopa and blocked by reserpine (chronic effect), alpha-methyldopa, pimozide, chlorpromazine, haloperidol and metoclopramide. Prazosin and clonidine partially blocked morphine SR in high doses. 4. Propranolol, yohimbine, cyproheptadine and atropine were ineffective in blocking morphine SR. 5. The results indicate that morphine SR is mediated through release of DA in the CNS which excites central D2 receptors. Activation of central alpha 1-adrenoceptors might also play a minor role.
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
July 2002,
The Journal of pharmacy and pharmacology,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
November 2016,
European journal of pharmacology,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
August 1994,
Neuroscience letters,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
July 1977,
Chemical & pharmaceutical bulletin,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
January 2001,
Pharmacology, biochemistry, and behavior,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
March 1994,
Neuroscience letters,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
September 1978,
Chemical & pharmaceutical bulletin,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
January 2015,
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
March 1978,
Chemical & pharmaceutical bulletin,
M L Gupta, and
R Nath, and
T K Gupta, and
G P Gupta
May 1979,
Chemical & pharmaceutical bulletin,
