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The incorporation of 3H-proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule. These plasma cells, which are often in close contact with the hepatocytes at the edge of the liver lobule, appear to be either negative or positive after the immunohistochemical tests for the k and lambda chains of immunoglobulins. Results are discussed in relation to both the synthesis of collagen and the role of the immunocompetent cells during the process of the piecemeal necrosis.
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
September 1984,
Sbornik lekarsky,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1978,
Acta gastro-enterologica Belgica,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1981,
Terapevticheskii arkhiv,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1986,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1981,
Gastroenterologia Japonica,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1980,
Terapevticheskii arkhiv,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1972,
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1974,
Ceskoslovenska gastroenterologie a vyziva,
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
October 1995,
Hepatology (Baltimore, Md.),
G Hassan, and
S Stefanini, and
A M Bargagli, and
F Autuori
January 1987,
Sovetskaia meditsina,
