Biomaterial Database

High-frequency oscillatory ventilation of a canine bronchopleural fistula. 1989

I Mayers, and J T Mink

Department of Medicine, University of Saskatchewan, Saskatoon, Canada.

We hypothesized that during high-frequency oscillatory ventilation (HFOV) of a central bronchopleural fistula (BPF), gas flow through the fistula (Vleak) should vary with ventilatory frequency. In six pentobarbital-anesthetized, open-chested dogs, we inserted a cannula into the left lower lobe bronchus. After 30 min of HFOV at 5 Hz (fistula closed), they received four periods of HFOV (fistula open) at frequencies of 5, 10, 15, and 20 Hz. With the fistula open, we could adequately ventilate at all four frequencies. Vleak ranged between 5.1 +/- 0.7 and 4.1 +/- 0.7 L/min and it was not significantly different at any frequency by analysis of variance. Airway opening pressure (Pao) was 3.9 +/- 0.6 cm H2O with the fistula closed. Pao decreased significantly to 1.9 +/- 0.2 cm H2O during 5 Hz ventilation (fistula open). Pao at the other frequencies was similar to fistula-closed ventilation. We believe that expiratory flow limitation at frequencies greater than 5 Hz may explain our findings.

UI	MeSH Term	Description	Entries
D010995	Pleural Diseases	Diseases involving the PLEURA.	Disease, Pleural,Diseases, Pleural,Pleural Disease
D011659	Pulmonary Gas Exchange	The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.	Exchange, Pulmonary Gas,Gas Exchange, Pulmonary
D001983	Bronchial Fistula	An abnormal passage or communication between a bronchus and another part of the body.	Bronchial Fistulas,Fistula, Bronchial,Fistulas, Bronchial
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005402	Fistula	Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.	Fistulas
D006612	High-Frequency Ventilation	Ventilatory support system using frequencies from 60-900 cycles/min or more. Three types of systems have been distinguished on the basis of rates, volumes, and the system used. They are high frequency positive-pressure ventilation (HFPPV); HIGH-FREQUENCY JET VENTILATION; (HFJV); and high-frequency oscillation (HFO).	High-Frequency Oscillation Ventilation,High-Frequency Positive Pressure Ventilation,Ventilation, High-Frequency,High Frequency Oscillation Ventilation,High Frequency Positive Pressure Ventilation,High Frequency Ventilation,Ventilation, High Frequency,High Frequency Ventilations,High-Frequency Oscillation Ventilations,High-Frequency Ventilations,Oscillation Ventilation, High-Frequency,Oscillation Ventilations, High-Frequency,Ventilation, High-Frequency Oscillation,Ventilations, High Frequency,Ventilations, High-Frequency,Ventilations, High-Frequency Oscillation
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia