This study aimed to evaluate the peri-implant strain around mesially inclined implants used to retain mandibular overdentures with Locator resilient attachments. Four mandibular edentulous acrylic resin models received two implants in the canine areas with 0°, 5°, 10°, and 20° mesial inclinations. Overdentures were connected to the implants using Locator attachments. Pink nylon inserts (light retention) were used for all implant inclinations, and red inserts were used for 20° inclination (20°red). Four strain gages were bonded on the mesial (M), distal (D), buccal (B), and lingual (L) surfaces of each implant. Peri-implant strains were measured during bilateral and unilateral loading. The 20° inclination showed the highest strain, followed by 10° and 5°, and both 0° and 20°red presented with the lowest strain. Site D was associated with the highest strain, followed by M, B, and L, which showed the lowest strain values. Unilateral loading and the loading side presented with significantly higher strain values than bilateral loading and the nonloading side, respectively. Hence, in this study, strains around the two-implant-retained overdentures with Locator attachments increased with increases in mesial implant angulation, except when red male inserts were used.