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Design and chemical synthesis of eukaryotic chromosomes. 2017

Ze-Xiong Xie, and Duo Liu, and Bing-Zhi Li, and Meng Zhao, and Bo-Xuan Zeng, and Yi Wu, and Yue Shen, and Tao Lin, and Ping Yang, and Junbiao Dai, and Yizhi Cai, and Huanming Yang, and Ying-Jin Yuan
Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. yjyuan@tju.edu.cn.

Following the discovery of the DNA double helix structure and the advancement of genome sequencing, we have entered a promising stage with regard to genome writing. Recently, a milestone breakthrough was achieved in the chemical synthesis of designer yeast chromosomes. Here, we review the systematic approaches to the de novo synthesis of designer eukaryotic chromosomes, with an emphasis on technologies and methodologies that enable design, building, testing and debugging. The achievement of chemically synthesized genomes with customized genetic features offers an opportunity to rebuild genome organization, remold biological functions and promote life evolution, which will be of great benefit for application in medicine and industrial manufacturing.

UI MeSH Term Description Entries
D015825 Chromosomes, Fungal Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell. Chromosome, Fungal,Fungal Chromosome,Fungal Chromosomes
D056890 Eukaryota One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista. Eukaryotes,Eucarya,Eukarya,Eukaryotas,Eukaryote

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