-transparent.png){kind=logo}
An acyclic derivative of 3'-azido-3'-deoxythymidine, (R,S)-1-[1-(2-hydroxyethoxy)-3-azidopropyl]thymine (2), has been synthesized by a path involving Michael-type addition. Related thymidine analogues lacking the C(3')-C(4') bond were similarly obtained. The method provides a versatile new route to nucleoside analogues. The new compounds were found to be essentially inactive against human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro when tested up to 100 microM.
Related Publications
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
June 2000,
Bioorganic & medicinal chemistry,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
January 1989,
Advances in experimental medicine and biology,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
November 2001,
Journal of medicinal chemistry,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
January 1981,
Acta microbiologica Academiae Scientiarum Hungaricae,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
January 1995,
Postepy biochemii,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
January 1998,
Advances in experimental medicine and biology,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
September 2012,
Medicinal chemistry (Shariqah (United Arab Emirates)),
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
September 1994,
Journal of medicinal chemistry,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
July 2010,
Nucleosides, nucleotides & nucleic acids,
P Scheiner, and
A Geer, and
A M Bucknor, and
J L Imbach, and
R F Schinazi
February 2009,
Nucleosides, nucleotides & nucleic acids,
