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We evaluated the clinical and analytical performance of the new immunochemiluminometric assay (ICMA; Ciba Corning) for measurement of creatine kinase isoenzyme MB (CK-MB), and compared it with three other methods: immunoradiometric assay (IRMA; International Immunoassay Labs); immunoinhibition assay (Seradyn); and an immunoinhibition/column method (Du Pont). Intra-test precision for all kits was good. We evaluated 32 patients' samples by all four methodologies. Only one of the four methods (aca, Du Pont) showed evidence of linearity. Efficiency in the diagnosis of myocardial injury in our study ranged from 53% (Seradyn) to 96% (Du Pont). We evaluated serial specimens from 20 separate patients by the IRMA and the ICMA to determine whether myocardial injury could be diagnosed earlier by the ICMA. In patients with acute myocardial infarction, the ICMA displayed positive values earlier and longer than the IRMA, suggesting that the ICMA is suited for screening for myocardial damage in hospitalized patients.
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
January 1986,
Clinical chemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
December 1977,
Lancet (London, England),
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
October 1977,
Clinica chimica acta; international journal of clinical chemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
July 1986,
Annals of clinical biochemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
December 1983,
Clinical chemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
August 1990,
Clinical chemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
June 1981,
Clinical chemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
January 1985,
Clinical chemistry,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
January 1984,
Rinsho byori. The Japanese journal of clinical pathology,
J G Schwartz, and
R W Brown, and
C A McMahan, and
C L Gage, and
S A Herber
September 1985,
Clinical chemistry,
