Management of organ motion in scanned ion beam therapy. 2017

Christoph Bert, and Klaus Herfarth
Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany. christoph.bert@uk-erlangen.de.

Scanned ion beam therapy has special demands for treatment of intra-fractionally moving tumors such as lesions in lung or liver. Interplay effects between beam and organ motion can in those settings lead to under-dosage of the target volume. Dedicated treatment techniques such as gating or abdominal compression are required. In addition 4D treatment planning should be used to determine strategies for patient specific treatment planning such as an increased beam focus or the use of internal target volumes incorporating range changes.Several work packages of the Clinical Research Units 214 and 214/2 funded by the German Research Council investigated the management of organ motion in scanned ion beam therapy. A focus was laid on 4D treatment planning using TRiP4D and the development of motion mitigation strategies including their quality assurance. This review focuses on the activity in the second funding period covering adaptive treatment planning strategies, 4D treatment plan optimization, and the application of motion management in pre-clinical research on radiation therapy of cardiac arrhythmias.

UI MeSH Term Description Entries
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D011880 Radiotherapy Planning, Computer-Assisted Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy. Computer-Assisted Radiotherapy Planning,Dosimetry Calculations, Computer-Assisted,Planning, Computer-Assisted Radiotherapy,Calculation, Computer-Assisted Dosimetry,Calculations, Computer-Assisted Dosimetry,Computer Assisted Radiotherapy Planning,Computer-Assisted Dosimetry Calculation,Computer-Assisted Dosimetry Calculations,Dosimetry Calculation, Computer-Assisted,Dosimetry Calculations, Computer Assisted,Planning, Computer Assisted Radiotherapy,Radiotherapy Planning, Computer Assisted
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000075530 Organ Motion Movement of internal organs due to physiological processes.
D016477 Artifacts Any visible result of a procedure which is caused by the procedure itself and not by the entity being analyzed. Common examples include histological structures introduced by tissue processing, radiographic images of structures that are not naturally present in living tissue, and products of chemical reactions that occur during analysis. Artefacts,Artefact,Artifact
D056973 Four-Dimensional Computed Tomography Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging. 4D CAT Scan,4D CT,4D CT Scan,4D Computed Tomography,Four-Dimensional CAT Scan,Four-Dimensional CT,Four-Dimensional CT Scan,4D CAT Scans,4D CT Scans,CAT Scan, 4D,CAT Scan, Four-Dimensional,CAT Scans, 4D,CAT Scans, Four-Dimensional,CT Scan, 4D,CT Scan, Four-Dimensional,CT Scans, 4D,CT Scans, Four-Dimensional,CT, Four-Dimensional,CTs, Four-Dimensional,Computed Tomography, 4D,Computed Tomography, Four-Dimensional,Four Dimensional CAT Scan,Four Dimensional CT,Four Dimensional CT Scan,Four Dimensional Computed Tomography,Four-Dimensional CAT Scans,Four-Dimensional CT Scans,Scan, 4D CAT,Scan, 4D CT,Scan, Four-Dimensional CAT,Scan, Four-Dimensional CT,Scans, 4D CAT,Scans, 4D CT,Scans, Four-Dimensional CAT,Scans, Four-Dimensional CT,Tomography, Four-Dimensional Computed
D063193 Heavy Ion Radiotherapy The use of a heavy ion particle beam for radiotherapy, such as the HEAVY IONS of CARBON. Carbon Ion Radiation Therapy,Carbon Ion Radiotherapy,Carbon Ion Therapy,Heavy Ion Radiation Therapy,Heavy Ion Therapy,Carbon Ion Therapies,Heavy Ion Radiotherapies,Heavy Ion Therapies,Radiotherapies, Heavy Ion,Radiotherapy, Carbon Ion,Radiotherapy, Heavy Ion,Therapies, Carbon Ion,Therapies, Heavy Ion,Therapy, Carbon Ion,Therapy, Heavy Ion

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