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The effects of adrenodemedullation and/or adrenoceptor agonists and antagonists on plasma epinephrine (E) and norepinephrine (NE) concentrations during exercise were investigated in rats. Exercise consisted of strenuous swimming against a countercurrent for 15 min in a pool with water of 33 degrees C. Before, during, and after swimming, blood samples were taken through a permanent heart catheter. E was not detectable in plasma of adrenodemedullated (Adm) rats. A marked reduction in the normal exercise-induced increase in plasma NE concentrations occurred in both Adm rats as well as in intact rats injected with the beta 2-selective adrenoceptor antagonist ICI 118551. Intravenous infusion of either E or the beta 2-selective agonist fenoterol restored the increase in plasma NE in Adm rats. Injection of the alpha 2-selective antagonist yohimbine in combination with infusion of the beta 2-selective agonist fenoterol into Adm rats caused an enormous increase in plasma NE. It is concluded that all NE in plasma as released during exercise originates from the peripheral nerve endings of the sympathetic nervous system. Adrenal E influences the release of NE via activation of presynaptic beta 2-adrenoceptors.
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
January 1982,
Medicine and science in sports and exercise,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
July 1987,
Journal of applied physiology (Bethesda, Md. : 1985),
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
January 1975,
Biology of the neonate,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
April 1978,
The Journal of pharmacology and experimental therapeutics,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
August 1980,
Medical biology,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
December 1968,
Doklady Akademii nauk SSSR,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
February 1992,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
November 1983,
Journal of applied physiology: respiratory, environmental and exercise physiology,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
July 1971,
Endocrinology,
A J Scheurink, and
A B Steffens, and
H Bouritius, and
G H Dreteler, and
R Bruntink, and
R Remie, and
J Zaagsma
January 1966,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
