Saccharomyces cerevisiae proteinase A excretion and wine making. 2017

Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People's Republic of China.

Proteinase A (PrA), the major protease in Saccharomyces cerevisiae, plays an essential role in zymogen activation, sporulation, and other physiological processes in vivo. The extracellular secretion of PrA often occurs during alcoholic fermentation, especially in the later stages when the yeast cells are under stress conditions, and affects the quality and safety of fermented products. Thus, the mechanism underlying PrA excretion must be explored to improve the quality and safety of fermented products. This paper briefly introduces the structure and physiological function of PrA. Two transport routes of PrA, namely, the Golgi-to-vacuole pathway and the constitutive Golgi-to-plasma membrane pathway, are also discussed. Moreover, the research history and developments on the mechanism of extracellular PrA secretion are described. In addition, it is briefly discussed that calcium homeostasis plays an important role in the secretory pathway of proteins, implying that the regulation of PrA delivery to the plasma membrane requires the involvement of calcium ion. Finally, this review focuses on the effects of PrA excretion on wine making (including Chinese rice wine, grape wine, and beer brewage) and presents strategies to control PrA excretion.

UI MeSH Term Description Entries
D011487 Protein Conformation The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). Conformation, Protein,Conformations, Protein,Protein Conformations
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D005285 Fermentation Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID. Fermentations
D005516 Food Microbiology The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept. Microbiology, Food
D006056 Golgi Apparatus A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990) Golgi Complex,Apparatus, Golgi,Complex, Golgi
D012441 Saccharomyces cerevisiae A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement. Baker's Yeast,Brewer's Yeast,Candida robusta,S. cerevisiae,Saccharomyces capensis,Saccharomyces italicus,Saccharomyces oviformis,Saccharomyces uvarum var. melibiosus,Yeast, Baker's,Yeast, Brewer's,Baker Yeast,S cerevisiae,Baker's Yeasts,Yeast, Baker
D014617 Vacuoles Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion. Vacuole
D014920 Wine Fermented juice of fresh grapes or of other fruit or plant products used as a beverage. Wines
D016282 Aspartic Acid Endopeptidases A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity. Aspartic Endopeptidases,Aspartyl Endopeptidases,Acid Endopeptidases, Aspartic,Endopeptidases, Aspartic Acid,Endopeptidases, Aspartyl

Related Publications

Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
January 2017, Frontiers in microbiology,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
January 1977, Genetics,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
May 2012, Applied and environmental microbiology,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
April 2006, FEMS microbiology letters,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
July 1996, Yeast (Chichester, England),
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
June 2007, Yeast (Chichester, England),
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
April 2019, Applied and environmental microbiology,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
September 2010, Applied microbiology and biotechnology,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
July 2023, Chemosphere,
Lulu Song, and Yefu Chen, and Yongjing Du, and Xibin Wang, and Xuewu Guo, and Jian Dong, and Dongguang Xiao
November 1975, Journal of bacteriology,
Copied contents to your clipboard!