-transparent.png){kind=logo}
Phosphatidylinositol metabolism, linked to muscarinic receptor activation, was studied in rat cortical slices after a unilateral quinolinic acid lesion to the nucleus basalis magnocellularis (nbM) or the cortex itself. The incorporation of [3H]inositol into inositol phosphate was measured in the presence of LiCl, followed by anion exchange chromatography to separate inositol phosphates. Carbachol produced a dose-related increase in the amount of inositol phosphate in both the control and the cortex from rats with lesions to the nbM. No significant difference in the accumulation of inositol phosphate was observed between the two groups. Destruction of cortical cells with quinolinic acid almost completely eliminated the activation of phosphatidylinositol metabolism by carbachol. These results suggest that muscarinic receptors linked to phosphatidylinositol metabolism in the cortex are localized on intrinsic cortical neurons and not on afferent terminals from basal forebrain cholinergic neurons.
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
January 1992,
Neurobiology of aging,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
March 1986,
Experimental neurology,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
January 1991,
Advances in experimental medicine and biology,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
August 1987,
Journal of neurochemistry,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
September 2009,
Georgian medical news,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
June 1990,
Research communications in chemical pathology and pharmacology,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
January 1993,
Experimental brain research,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
November 1992,
Japanese journal of pharmacology,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
August 1991,
Brain research bulletin,
B J Scarth, and
K Jhamandas, and
R J Boegman, and
R J Beninger, and
J N Reynolds
January 1994,
Journal of neural transmission. Supplementum,
