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Copper-Catalyzed Enantioselective Synthesis of β-Boron β-Amino Esters. 2017

Aurora López, and Timothy B Clark, and Alejandro Parra, and Mariola Tortosa

In this report, the enantioselective, copper-catalyzed borylation of β-amidoacrylates is disclosed. A broad variety of biologically important α-aminoboronates has been prepared with consistently high levels of enantiocontrol using an inexpensive copper catalyst and a commercially available chiral ligand. The method can be applied to the synthesis of novel boron-containing dipeptides and hemiboronates.

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