BIOMAT Database Logo BIOMAT Database Logo

Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats. 2018

Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Department of Pharmacology, Shanxi Medical University, Taiyuan, 030001, China. Electronic address: shiruizan@163.com.

Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder characterized by elevated pulmonary arterial pressure (PAP) and right ventricular hypertrophy (RVH) driven by progressive vascular remodeling. Reversing adverse vascular remodeling is an important concept in the treatment of PAH. Endothelial injury, inflammation, and oxidative stress are three main contributors to pulmonary vascular remodeling. Baicalein is a natural flavonoid that has been shown to possess anti-proliferative, anti-inflammatory, anti-oxidative, and cardioprotective properties. We hypothesized that baicalein may prevent the progression of PAH and preserve the right heart function by inhibiting pulmonary arterial remodeling. Male Sprague-Dawley rats were distributed randomly into 4 groups: control, monocrotaline (MCT)-exposed, and MCT-exposed plus baicalein treated rats (50 and 100 mg/kg/day for 2 weeks). Hemodynamic changes, RVH, and lung morphological features were examined on day 28. Apoptosis was determined by TUNEL staining, and the mRNA levels of tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and IL-6 were detected by qRT-PCR. The changes in oxidative indicators, including malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured using corresponding commercial kits. The levels of Bax, Bcl-2, and cleaved caspase-3, and the activation of mitogen-activated protein kinase (MAPK) and NF-κB were assessed by western blotting. MCT induced an increase in hemodynamic parameters and RVH, which were attenuated by baicalein treatment. Baicalein also blocked MCT-induced pulmonary arterial remodeling. The levels of apoptotic (Bax/Bcl-2 ratio and cleaved caspase-3) and inflammatory (IL-6, TNF-α, and IL-1β) biomarkers in lung tissue were lower in baicalein-treated groups. Baicalein also decreased MDA level, and increased SOD and GSH-Px activity in rat pulmonary tissue. Furthermore, baicalein inhibited MCT-induced activation of the MAPK and NF-κB pathways. Baicalein ameliorates MCT-induced PAH by inhibiting pulmonary arterial remodeling at least partially via the MAPK and NF-κB pathways in rats.

UI MeSH Term Description Entries
D006976 Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. Pulmonary Hypertension
D008297 Male Males
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine
D016328 NF-kappa B Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA. Immunoglobulin Enhancer-Binding Protein,NF-kappa B Complex,Nuclear Factor kappa B,Transcription Factor NF-kB,kappa B Enhancer Binding Protein,Ig-EBP-1,NF-kB,NF-kappaB,Nuclear Factor-Kappab,Complex, NF-kappa B,Enhancer-Binding Protein, Immunoglobulin,Factor NF-kB, Transcription,Factor-Kappab, Nuclear,Ig EBP 1,Immunoglobulin Enhancer Binding Protein,NF kB,NF kappa B Complex,NF kappaB,NF-kB, Transcription Factor,Nuclear Factor Kappab,Transcription Factor NF kB
D016686 Monocrotaline A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment. Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer,Monocrotaline, (all-xi)-Isomer

Related Publications

Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Formononetin attenuates monocrotaline‑induced pulmonary arterial hypertension via inhibiting pulmonary vascular remodeling in rats.
December 2019, Molecular medicine reports,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Thymoquinone attenuates monocrotaline-induced pulmonary artery hypertension via inhibiting pulmonary arterial remodeling in rats.
October 2016, International journal of cardiology,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Spermidine attenuates monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting purine metabolism and polyamine synthesis-associated vascular remodeling.
May 2024, International immunopharmacology,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Celastrol attenuates the remodeling of pulmonary vascular and right ventricular in monocrotaline-induced pulmonary arterial hypertension in rats.
February 2022, Cardiovascular diagnosis and therapy,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Betaine Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibiting Inflammatory Response.
May 2018, Molecules (Basel, Switzerland),
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats.
September 2009, Circulation journal : official journal of the Japanese Circulation Society,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats.
January 2019, Drug design, development and therapy,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Progesterone inhibits vascular remodeling and attenuates monocrotaline-induced pulmonary hypertension in estrogen-deficient rats.
July 2009, Prilozi,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.
December 2015, JACC. Cardiovascular interventions,
Ruizan Shi, and Zehui Wei, and Diying Zhu, and Naijie Fu, and Chang Wang, and Sha Yin, and Yueqin Liang, and Jianfeng Xing, and Xuening Wang, and Yan Wang
Calorie Restriction Attenuates Monocrotaline-induced Pulmonary Arterial Hypertension in Rats.
June 2015, Journal of cardiovascular pharmacology,
Copied contents to your clipboard!