BIOMAT Database Logo BIOMAT Database Logo

Regulation of T helper cell responses during antigen presentation by norepinephrine-exposed endothelial cells. 2018

Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

Dermal blood vessels and regional lymph nodes are innervated by sympathetic nerves and, under stress, sympathetic nerves release norepinephrine (NE). Exposure of primary murine dermal microvascular endothelial cells (pDMECs) to NE followed by co-culture with Langerhans cells (LCs), responsive CD4+ T-cells and antigen resulted in modulation of CD4+ T-cell responses. NE-treatment of pDMECs induced increased production of interleukin (IL)-6 and IL-17A while down-regulating interferon (IFN)-γ and IL-22 release. This effect did not require contact between pDMECs and LCs or T-cells and depended upon pDMEC production of IL-6. The presence of NE-treated pDMECs increased the proportion of CD4+ T-cells expressing intracellular IL-17A and increased IL-17A mRNA while decreasing the proportion of IFN-γ- or IL-22-expressing CD4+ T-cells and mRNA levels for those cytokines. Retinoic acid receptor-related orphan receptor gamma (ROR-γt) mRNA was significantly increased in CD4+ T-cells while T-box transcription factor (T-bet) mRNA was decreased. Intradermal administration of NE prior to hapten immunization at the injection site produced a similar bias in draining lymph node CD4+ T-cells towards IL-17A and away from IFN-γ and IL-22 production. Under stress, release of NE may have significant regulatory effects on the outcome of antigen presentation through actions on ECs with enhancement of inflammatory skin disorders involving IL-17/T helper type 17 (Th17) cells.

UI MeSH Term Description Entries
D007378 Interleukins Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli. Interleukin
D007801 Langerhans Cells Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS. Langerhans Cell,Dendritic Cells, Dermal,Dendritic Cells, Epidermal,Dendritic Cells, Skin,Dermal Dendritic Cells,Epidermal Dendritic Cells,Skin Dendritic Cells,Cell, Dermal Dendritic,Cell, Epidermal Dendritic,Cell, Langerhans,Cell, Skin Dendritic,Cells, Dermal Dendritic,Cells, Epidermal Dendritic,Cells, Langerhans,Cells, Skin Dendritic,Dendritic Cell, Dermal,Dendritic Cell, Epidermal,Dendritic Cell, Skin,Dermal Dendritic Cell,Epidermal Dendritic Cell,Skin Dendritic Cell
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D009638 Norepinephrine Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D002450 Cell Communication Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP. Cell Interaction,Cell-to-Cell Interaction,Cell Communications,Cell Interactions,Cell to Cell Interaction,Cell-to-Cell Interactions,Communication, Cell,Communications, Cell,Interaction, Cell,Interaction, Cell-to-Cell,Interactions, Cell,Interactions, Cell-to-Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005260 Female Females

Related Publications

Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses.
June 2020, Cellular & molecular immunology,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
[Mechanism of antigen presentation by B cells to helper T cells].
January 1987, Postepy higieny i medycyny doswiadczalnej,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Endothelial cell presentation of antigen to human T cells.
November 1981, Human immunology,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Effective antigen presentation to helper T cells by human eosinophils.
December 2016, Immunology,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Tracking antigen-specific helper T cell responses.
April 1996, Current opinion in immunology,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Regulation of T follicular helper cell formation and function by antigen presenting cells.
February 2011, Current opinion in immunology,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
T cell regulation of antibody responses: an I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses.
February 1985, Journal of immunology (Baltimore, Md. : 1950),
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation.
January 2008, Journal of immunology (Baltimore, Md. : 1950),
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
Regulation of T cell expansion by antigen presentation dynamics.
March 2019, Proceedings of the National Academy of Sciences of the United States of America,
Linghui Xu, and Wanhong Ding, and Lori L Stohl, and Xi K Zhou, and Shayan Azizi, and Ethan Chuang, and Jimmy Lam, and John A Wagner, and Richard D Granstein
T cell responses induced by the parenteral injection of antigen-modified syngeneic cells. I. Induction, characterization, and regulation of antigen-specific T helper cells involved in delayed-type hypersensitivity responses.
July 1983, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!