Intravenous magnesium sulfate in the management of acute respiratory failure complicating asthma. 1989

R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
Department of Emergency Medicine, Medical College of Pennsylvania, Philadelphia 19129.

IV magnesium sulfate was administered to a 72-year-old man with acute respiratory failure secondary to a severe asthma attack. The patient had clinically deteriorated despite aggressive standard treatment and evidenced acidosis and hypercarbia by arterial blood gas determination. An IV dose of 1 g MgSO4 produced rapid clinical and arterial blood gas improvement and enabled management of the patient without endotracheal intubation and mechanical ventilation. This is the first reported case of the use of IV MgSO4 to prevent intubation and assisted ventilation in a patient with acute respiratory failure complicating asthma.

UI MeSH Term Description Entries
D007262 Infusions, Intravenous The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it. Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D008278 Magnesium Sulfate A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Magnesium Sulfate, Heptahydrate,Heptahydrate Magnesium Sulfate,Sulfate, Magnesium
D008297 Male Males
D012131 Respiratory Insufficiency Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed) Acute Hypercapnic Respiratory Failure,Acute Hypoxemic Respiratory Failure,Hypercapnic Acute Respiratory Failure,Hypercapnic Respiratory Failure,Hypoxemic Acute Respiratory Failure,Hypoxemic Respiratory Failure,Respiratory Depression,Respiratory Failure,Ventilatory Depression,Depressions, Ventilatory,Failure, Hypercapnic Respiratory,Failure, Hypoxemic Respiratory,Failure, Respiratory,Hypercapnic Respiratory Failures,Hypoxemic Respiratory Failures,Respiratory Failure, Hypercapnic,Respiratory Failure, Hypoxemic,Respiratory Failures
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas

Related Publications

R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
January 1990, JAMA,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
February 1995, Journal of emergency nursing,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
September 2000, Respirology (Carlton, Vic.),
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
January 2019, American family physician,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
November 1991, Annals of emergency medicine,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
June 2022, BMJ case reports,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
October 2020, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
May 1997, Indian pediatrics,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
February 1990, Chest,
R M McNamara, and W H Spivey, and E Skobeloff, and S Jacubowitz
June 1995, Chest,
Copied contents to your clipboard!