Visual field asymmetries were examined in American Sign Language-English bilinguals for speeded numerical size judgments of pairs of digits, number words, and number signs. Physical size of the number pairs was either congruent or incongruent with their numerical size. The results revealed a greater left visual field (LVF) interference for numbers represented as digits and a greater right visual field (RVF) interference for numbers represented as words or signs. Subjects' performance on number words and signs was also influenced by their skill in English and ASL: interference was greater in the RVF in the subjects' better language but was greater in the LVF for the less skilled language. These findings suggest that lateralization of numerical size judgments is moderated by the mode of number presentation and by prior language experience.