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Immunopotentiation by cytostatic drugs continuously released from osmotic minipumps, was investigated in a guinea-pig contact-sensitivity model. These pumps are designed to release their content within a period of 7 days. Vepeside (VP-16) and 5-fluorouracil were released into oxazolone-stimulated lymph nodes by subcutaneous implantation of pumps containing either of these drugs. The pumps were implanted at the intended sensitization site, 2 days before sensitization. Strong potentiation of T-cell-mediated immunity, evaluated by delayed-type hypersensitivity measurements, was observed with both drugs tested. Daily injections with VP-16 also caused an enhancement of the immune response. However, daily injections with 5-fluorouracil, a drug assumed to be cell-cycle-specific in its action, failed to potentiate delayed hypersensitivity to oxazolone. Intralesional administration of cytostatic drugs has been put forward as an effective treatment modality in various types of cancer. Therapeutic effects may depend on both local tumor cytotoxic and immunopotentiating activities. Our present results suggest that osmotic minipumps can be applied to broaden the applicability and effectiveness of local chemotherapy.
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
January 1970,
Folia allergologica,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
May 1978,
Cellular immunology,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
January 2008,
Blood cells, molecules & diseases,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
May 1990,
The Journal of investigative dermatology,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
January 1983,
Haematology and blood transfusion,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
October 1985,
Klinische Wochenschrift,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
January 2000,
Chirurgia italiana,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
August 1991,
Trends in pharmacological sciences,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
January 1981,
Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Oto-rino-laringologia,
A M Claessen, and
H Valster, and
H Bril, and
S Meyer, and
R J Scheper
August 1978,
American journal of ophthalmology,
