To summarized clinical features of Behcet's patients with conduction disturbances and explore the underlying risk factors. A retrospective case-control study was conducted in Anzhen Hospital, Capital Medical University. Demographic data, clinical features, laboratory results, treatments, and fatality rate during hospital stay were analyzed. We found 23.1% of Behcet's disease had conduction disturbances and 84.0% had aortic valvular insufficiency. The male percentage of the Behcet's disease patients with conduction disturbances was significantly higher than controls (88.9 vs. 61.7%, P = 0.03). The echocardiography showed left ventricular end-diastolic diameter [64.00 (18) vs. 48.00 (15) mm, P = 0.000]; left ventricular end-contraction diameter [47.50 (11) vs. 30 (13) mm, P = 0.000]; left atrial diameter [47 (17) vs. 34 (14) mm, P = 0.001]; and left ventricular ejection fraction [60 (10) vs. 63 (13) mm, P = 0.023] were significantly different between two groups. Aortic valvular insufficiency was an independent risk factor for Behcet's disease with conduction disturbances (OR = 17.830; 95% CI 2.106, 150.981; P = 0.008). Conduction disturbance in Behcet's disease deserved attention. The diagnosis of BD and evaluation of conduction disturbance should be kept in mind when accepting patients with valvular regurgitation.