-transparent.png){kind=logo}
We have studied the effect of a pharmacological dose of testosterone enanthate (3 mg.kg-1.wk-1 for 12 wk) on muscle mass and total-body potassium and on whole-body and muscle protein synthesis in normal male subjects. Muscle mass estimated by creatinine excretion increased in all nine subjects (20% mean increase, P less than 0.02); total body potassium mass estimated by 40K counting increased in all subjects (12% mean increase, P less than 0.0001). In four subjects, a primed continuous infusion protocol with L-[1-13C]leucine was used to determine whole-body leucine flux and oxidation. Whole-body protein synthesis was estimated from nonoxidative flux. Muscle protein synthesis rate was determined by measuring [13C]leucine incorporation into muscle samples obtained by needle biopsy. Testosterone increased muscle protein synthesis in all subjects (27% mean increase, P less than 0.05). Leucine oxidation decreased slightly (17% mean decrease, P less than 0.01), but whole-body protein synthesis did not change significantly. Muscle morphometry showed no significant increase in muscle fiber diameter. These studies suggest that testosterone increases muscle mass by increasing muscle protein synthesis.
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
December 1976,
Growth,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
January 1998,
Ugeskrift for laeger,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
March 1996,
The British journal of surgery,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
October 1996,
The Journal of clinical endocrinology and metabolism,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
August 1971,
The Journal of endocrinology,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
January 1986,
The Italian journal of biochemistry,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
February 1970,
Biochemistry,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
July 2022,
The Journal of clinical endocrinology and metabolism,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
December 2017,
The Journal of nutrition,
R C Griggs, and
W Kingston, and
R F Jozefowicz, and
B E Herr, and
G Forbes, and
D Halliday
January 2003,
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994),
