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X-Rays, ethyl methanesulfonate and ICR-191 induced 2 classes of trifluorothymidine-resistant mutants at the autosomal tk locus in human lymphoblastoid cells. These classes were differentiated by their growth rates; some mutants grew with a normal doubling time of 14-18 h (tk-NG), while others grew much more slowly, with doubling times of 21-44 h (tk-SG). Only mutants with normal growth rates were observed at the X-linked hprt locus; the frequencies of mutations induced at hprt were equal to those induced for tk-NG mutants. Thus, more mutations overall (by up to a factor of 6) were induced at tk than at hprt. These results are discussed in relation to recent studies in rodent cells, in which much greater mutation frequencies were observed at autosomal loci.
H L Liber, and
D W Yandell, and
J B Little
October 1994,
Mutation research,
H L Liber, and
D W Yandell, and
J B Little
July 2001,
Mutation research,
H L Liber, and
D W Yandell, and
J B Little
January 2002,
Environmental and molecular mutagenesis,
H L Liber, and
D W Yandell, and
J B Little
January 1994,
Environmental and molecular mutagenesis,
H L Liber, and
D W Yandell, and
J B Little
March 1991,
Mutation research,
H L Liber, and
D W Yandell, and
J B Little
January 2007,
Environmental and molecular mutagenesis,
H L Liber, and
D W Yandell, and
J B Little
October 1996,
Toxicology in vitro : an international journal published in association with BIBRA,
H L Liber, and
D W Yandell, and
J B Little
September 1993,
Trends in genetics : TIG,
H L Liber, and
D W Yandell, and
J B Little
September 1994,
Mutation research,
H L Liber, and
D W Yandell, and
J B Little
May 1993,
Journal of molecular biology,
