OBJECTIVE We report a case of atypical esophageal stricture in a young diabetic woman. BACKGROUND Diabetes mellitus and gastroesophageal reflux disease (GERD) are two common disorders in modern society. METHODS A young diabetic woman developed a 6-cm-long esophageal stricture. This stricture was refractory to multiple esophageal dilation procedures. She underwent subtotal esophagectomy and had excellent treatment outcome. CONCLUSIONS Gastroesophageal reflux disease can cause severe long esophageal stricture in a brittle diabetic. CONCLUSIONS Improving the awareness of their association between diabetes and GERD would greatly benefit the day-to-day practice of medicine.How to cite this article: Pak SC, Darr U, Alastal Y, Yoon Y. Long Esophageal Stricture in a Brittle Diabetic. Euroasian J Hepato-Gastroenterol 2017;7(2):191-192.