BIOMAT Database Logo BIOMAT Database Logo

Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory. 2017

Edward J Steele
CYO'Connor ERADE Village Foundation Inc., Piara Waters, WA, Australia.

The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet's Clonal Selection Theory, the evidence is briefly reviewed and updated.

UI MeSH Term Description Entries

Related Publications

Edward J Steele
Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas.
June 2003, Cancer research,
Edward J Steele
The clonal selection theory: 50 years since the revolution.
October 2007, Nature immunology,
Edward J Steele
The clonal-selection theory.
August 1987, Scientific American,
Edward J Steele
Analysis of somatic hypermutation and antigenic selection in the clonal B cell in immunoglobulin light chain amyloidosis (AL).
July 2004, Journal of clinical immunology,
Edward J Steele
Testing the reverse transcriptase model of somatic mutation.
August 2001, Molecular immunology,
Edward J Steele
Somatic hypermutation.
April 1995, Current opinion in immunology,
Edward J Steele
Antibody Dynamics Simulation-A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation.
July 2023, Biomedicines,
Edward J Steele
Somatic clonal evolution: A selection-centric perspective.
April 2017, Biochimica et biophysica acta. Reviews on cancer,
Edward J Steele
Clonal selection in the germinal centre by regulated proliferation and hypermutation.
May 2014, Nature,
Edward J Steele
Mechanism and fidelity of HIV reverse transcriptase.
December 1992, The Journal of biological chemistry,
Copied contents to your clipboard!