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An early-onset, familial form of Alzheimer's disease (AD) has been reported to be linked to a locus on the long arm of chromosome 21 (21q21). Furthermore, duplications in the vicinity of this locus involving the beta-amyloid gene and the proto-oncogene ets-2 have been reported in association with AD. The structural gene for Cu,Zn superoxide dismutase, SOD-1, is located between the beta-amyloid gene and ets-2. For this reason and because SOD-1 is a plausible candidate for a gene that might influence the fluidity of cellular membranes, we determined whether or not the subtype of AD with increased platelet membrane fluidity was associated with an increase in Cu,Zn superoxide dismutase activity.
G S Zubenko, and
P Sauer
July 1987,
The American journal of psychiatry,
G S Zubenko, and
P Sauer
December 1988,
Biological psychiatry,
G S Zubenko, and
P Sauer
October 1987,
Science (New York, N.Y.),
G S Zubenko, and
P Sauer
December 1988,
Biological psychiatry,
G S Zubenko, and
P Sauer
November 1994,
Neuroreport,
G S Zubenko, and
P Sauer
September 1988,
Archives of neurology,
G S Zubenko, and
P Sauer
January 1999,
Neurologia i neurochirurgia polska,
G S Zubenko, and
P Sauer
January 1987,
Progress in neuro-psychopharmacology & biological psychiatry,
G S Zubenko, and
P Sauer
August 1991,
Stroke,
G S Zubenko, and
P Sauer
July 1991,
Acta neurologica Scandinavica,
